Bacteria over-expressing c-di-AMP and therapeutic methods
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United States of America Patent
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Nov 20, 2018
Grant Date -
Feb 1, 2018
app pub date -
Feb 10, 2016
filing date -
Feb 11, 2015
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Abstract
The present invention includes the discovery of a strain of Mycobacterium comprising an expression vector encoding a di-adenylate cyclase enzyme. The Mycobacterium is selected from the group consisting of Mycobacterium tuberculosis, Mycobacterium bovis, or a combination thereof and the preferred strain of Mycobacterium is BCG. The preferred expression vector is a mycobacterial expression vector including an hsp60 promoter and a DNA sequence of diadenylate cyclase (disA), or a functional part thereof. The strains of Mycobacterium are used in therapeutic applications including tuberculosis and cancer.
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