SUBSTRATE/PEPTIDE/LIPID BILAYER ASSEMBLY, PREPARATION METHODS AND ASSOCIATED DETECTION METHODS

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United States of America Patent

SERIAL NO

15520896

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Abstract

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The invention concerns an assembly consisting of a substrate on which at least one lipid bilayer is attached by means of a peptide, referred to as the tethering peptide, which is itself linked to the substrate, characterised in that the tethering peptide has a C-terminal end constituted by at least four consecutive histidines and in that the lipid bilayer comprises a portion of lipids having a chelating headgroup enclosing a metal cation providing the link with the tethering peptide as a result of metal-chelate interactions between the metal cation and at least a portion of the histidines located at the C-terminal position of the tethering peptide; and the method for preparing same and the associated detection methods.

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Patent Owner(s)

Patent OwnerAddress
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE3 RUE MICHEL ANGE 75016 PARIS FRANCE
UNIVERSITE CLAUDE BERNARD LYON I43 BOULEVARD DU 11 NOVEMBRE 1918 VILLEURBANNE CEDEX 69622
ECOLE SUPERIEURE DE CHIMIE PHYSIQUE ELECTRONIQUE DE LYON43 BOULEVARD DU 11 NOVEMBRE 1918 VILLEURBANNE CEDEX 69616
INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON20 AVENUE ALBERT EINSTEIN VILLEURBANNE CEDEX 69621

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
GIRARD-EGROT, Agnes BEYNOST, FR 1 0
MANITI, Ofelia LA TOUR DU PIN, FR 2 0
REBAUD, Samuel SAINT-ETIENNE, FR 1 0

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