NOVEL METHODS, COMPOUNDS, AND COMPOSITIONS FOR ANESTHESIA
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United States of America Patent
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Jan 25, 2018
app pub date -
Oct 16, 2015
filing date -
Oct 16, 2014
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Abstract
Methods of treatment useful in the inducement or maintenance of anesthesia in a subject are provided. The methods comprise administering to a subject in need of anesthesia a compound disclosed herein. Also provided are novel compounds having anesthetic effects, pharmaceutical compositions comprising the compounds, and packaged pharmaceuticals. Computer modeling of the compounds demonstrates favorable interactions with the GABA receptor type A. In addition, the compounds display reversible anesthetic effects in an animal model, with dose-response curves similar to those of known general anesthetics. GABA receptor-mediated effects are also demonstrated in a hippocampal brain slice preparation.
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