Targeted radiotherapy chelates for in situ immune modulated cancer vaccination
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United States of America Patent
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Aug 25, 2020
Grant Date -
Jan 25, 2018
app pub date -
Jul 25, 2017
filing date -
Jul 25, 2016
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Abstract
The disclosed method of treating a malignant solid tumor in a subject includes the steps of administering to the subject an immunomodulatory dose of a radioactive phospholipid metal chelate compound that is differentially retained within malignant solid tumor tissue, and performing in situ tumor vaccination in the subject by introducing into at least one of the malignant solid tumors one or more agents capable of stimulating specific immune cells within the tumor microenvironment, or by performing another method of in situ tumor vaccination. In a non-limiting example, the radioactive phospholipid metal chelate compound has the formula:
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