Liposomal particles comprising biological molecules and uses thereof
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United States of America Patent
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Jun 4, 2019
Grant Date -
Jan 25, 2018
app pub date -
Jan 28, 2016
filing date -
Jan 30, 2015
priority date (Note) -
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Abstract
Provided herein are liposomal particles. In particular, provided herein are liposomal particles comprising molecules (e.g., antigens or drugs) and uses thereof (e.g., as a vaccine (e.g., intranasal vaccine) or drug delivery system). For example, in some embodiments, the present disclosure provides a composition comprising: a molecule encapsulated in a liposome comprising one or more cationic lipids and hyaluronic acid (HA). In some embodiments, the one or more lipids are DOTAP and/or DOPE. In some embodiments, the HA is thiolated. In some embodiments, the thiolated HA is conjugated to thiolated PEG.
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