Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces
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United States of America Patent
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Nov 26, 2019
Grant Date -
Jan 25, 2018
app pub date -
Jan 26, 2016
filing date -
Jan 27, 2015
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Abstract
Hypotonic formulations of hydrogel forming polymers, preferably poloxamers, have been developed for enhanced delivery through mucosa of therapeutic, diagnostic, prophylactic or other agents, to epithelial tissues, especially those having a mucosal coating. The polymers are administered at a concentration above, at or less than their critical gelling concentration (CGC) under isotonic conditions. The hypotonicity of the formulation is adjusted so that the polymer gels at the lower concentration. A Poloxamer gel administered into the vagina or colorectum at its CGC will form a “plug” of gel in the lumen.
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