Treatment or prevention of surgery-induced cachexia and/or expression of myeloid-derived suppressor cells and pro-inflammatory cytokines

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United States of America Patent

PATENT NO 11857525
APP PUB NO 20180021279A1
SERIAL NO

15548186

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A specialized immunonutrition supplement can be administered to a surgical patient to reduce post-operative complications by restraining the expansion of myeloid-derived suppressor cells. The supplement includes one or more of L-arginine, omega-3 fatty acids, vitamin A, and dietary nucleotides, preferably all four of these compounds. The supplement is administered to the patient at least once per day for a time period extending from a pre-operative day that is three to seven days prior to a bladder surgery of the patient to a post-operative day that is three to seven days after the bladder surgery. The supplement can be administered to treat or prevent post-operative paralytic ileus in a bladder cancer patient; treat or prevent surgery-induced, inflammation-induced or cancer-induced cachexia; reduce the incidence of chronic infections resulting from expansion of myeloid-derived suppressor cells in a patient; and/or reduce mRNA expression of pro-inflammatory cytokines in a patient.

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Patent Owner(s)

  • SOCIETE DES PRODUITS NESTLE SA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hamilton-Reeves, Jill Shawnee, US 2 2
Holzbeierlein, Jeffrey M Mission Hills, US 2 2
Yankee, Thomas Overland Park, US 5 5

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