Method of segmenting single neuron images with high-dynamic-range thresholds and computer readable storage medium thereof

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United States of America Patent

PATENT NO 10002425
SERIAL NO

15369897

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The method of segmenting single neuron images with high-dynamic-range thresholds of the present invention includes (a) preparing a biological tissue sample containing neurons and performing imaging to this sample to obtain a three-dimensional raw neuroimage; (b) deleting voxels in the three-dimensional raw neuroimage with signal intensities below a first signal intensity threshold to obtain a first thresholded image; (c) tracing the first thresholded image to obtain a first traced image; (d) calculating a structural importance score of every voxel in the first traced image to obtain a first structural importance score of every voxel; (e) gradually increasing the signal intensity threshold and repeating (b), (c) and (d) n−1 times; (f) summing up all the n structural importance scores of every voxel; (g) deleting voxels with summed structural importance score smaller than a pre-determined value from the raw image to obtain the segmented single neuron.

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Patent Owner(s)

Patent OwnerAddress
NATIONAL APPLIED RESEARCH LABORATORIES3F NO 106 SEC 2 HEPING E RD DA'AN DIST TAIPEI CITY 106
NATIONAL TSING HUA UNIVERSITYHSINCHU
TUNGHAI UNIVERSITYNO 1727 SEC 4 TAIWAN BLVD XITUN DIST TAICHUNG CITY 407

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Nan-Yow Hsinchu, TW 3 7
Chiang, Ann-Shyn Hsinchu, TW 32 235
Shih, Chi-Tin Taichung, TW 1 1

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