Method of segmenting single neuron images with high-dynamic-range thresholds and computer readable storage medium thereof
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United States of America Patent
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app pub date -
Dec 6, 2016
filing date -
Jul 12, 2016
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Abstract
The method of segmenting single neuron images with high-dynamic-range thresholds of the present invention includes (a) preparing a biological tissue sample containing neurons and performing imaging to this sample to obtain a three-dimensional raw neuroimage; (b) deleting voxels in the three-dimensional raw neuroimage with signal intensities below a first signal intensity threshold to obtain a first thresholded image; (c) tracing the first thresholded image to obtain a first traced image; (d) calculating a structural importance score of every voxel in the first traced image to obtain a first structural importance score of every voxel; (e) gradually increasing the signal intensity threshold and repeating (b), (c) and (d) n−1 times; (f) summing up all the n structural importance scores of every voxel; (g) deleting voxels with summed structural importance score smaller than a pre-determined value from the raw image to obtain the segmented single neuron.
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- 15 United States
- 10 France
- 8 Japan
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- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
NATIONAL APPLIED RESEARCH LABORATORIES | 3F NO 106 SEC 2 HEPING E RD DA'AN DIST TAIPEI CITY 106 | |
NATIONAL TSING HUA UNIVERSITY | HSINCHU | |
TUNGHAI UNIVERSITY | NO 1727 SEC 4 TAIWAN BLVD XITUN DIST TAICHUNG CITY 407 |
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Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Chen, Nan-Yow | Hsinchu, TW | 3 | 7 |
# of filed Patents : 3 Total Citations : 7 | |||
Chiang, Ann-Shyn | Hsinchu, TW | 32 | 235 |
# of filed Patents : 32 Total Citations : 235 | |||
Shih, Chi-Tin | Taichung, TW | 1 | 1 |
# of filed Patents : 1 Total Citations : 1 |
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