Glycosylated lysosomal proteins, method of production and uses

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United States of America Patent

PATENT NO 11401563
APP PUB NO 20180016648A1
SERIAL NO

15542998

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Abstract

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The present invention relates to a lysosomal protein composition comprising a plurality of lysosomal proteins that are potentially diversely glycosylated according to a glycosylation pattern, wherein said glycosylation pattern has at least 45% paucimannosidic N-glycans; a method of manufacturing the lysosomal protein composition in a bryophyte plant or cell, and medical and non-medical uses of the lysosomal protein composition. E.g. the lysosomal protein can be a-Galactosidase for the treatment of Fabry Disease or β-Glucoceramidase for the treatment of Gaucher's Disease. The unique glycosylation results in improved therapeutic efficacy—surprisingly even without mannose-6-phosphate that is common for CHO cell produced lysosomal proteins.

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ELEVA GMBH79108 FREIBURG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Benjamin, Fode Denzlingen, DE 2 2
Busch, Andreas Ebringen, DE 13 98
Dabrowska-Schlepp, Paulina Gundelfingen, DE 2 2
Niederkrüger, Holger Malterdingen, DE 3 2
Schaaf, Andreas Freiburg, DE 8 30

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