Methods for Modulating Genome Editing
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United States of America Patent
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Issued Date -
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app pub date -
Jul 13, 2017
filing date -
Jan 15, 2015
priority date (Note) -
Published
status (Latency Note)
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Abstract
Provided herein are methods and kits for modulating genome editing of target DNA. The invention includes using small molecules that enhance or repress homology-directed repair (HDR) and/or nonhomologous end joining (NHEJ) repair of double-strand breaks in a target DNA sequence. Also provided herein are methods for preventing or treating a genetic disease in a subject by enhancing precise genome editing to correct a mutation in a target gene associated with the genetic disease. Further provided herein are systems and methods for screening small molecule libraries to identify novel modulators of genome editing. The present invention can be used with any cell type and at any gene locus that is amenable to nuclease-mediated genome editing technology.
First Claim
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Family
| Country | kind | publication No. | Filing Date |
|---|---|---|---|
| CN | A | CN107429263 | Jan 14, 2016 |
| WO | A1 | WO2016115326 | Jan 14, 2016 |
International Classification(s)
- 2017 Application Filing Year
- A61K Class
- 21227 Applications Filed
- 12841 Patents Issued To-Date
- 60.50 % Issued To-Date
Cited Art Landscape
Patent Citation Ranking
- 6 Citation Count
- A61K Class
- 50.93 % this patent is cited more than
- 7 Age