Mice expressing polymorphic low affinity FcgammaR alpha-chains
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United States of America Patent
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Jan 18, 2018
app pub date -
May 22, 2017
filing date -
Dec 21, 2009
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Abstract
Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity FcγR locus, and wherein the mouse is capable of expressing a functional FcRγ-chain. Genetically modified mice are described, including mice that express low affinity human FcγR genes from the endogenous FcγR locus, and wherein the mice comprise a functional FcRγ-chain. Genetically modified mice that express up to five low affinity human FcγR genes on accessory cells of the host immune system are provided.
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