Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria

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United States of America Patent

PATENT NO 10265313
APP PUB NO 20180015086A1
SERIAL NO

15723677

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Abstract

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The invention provides methods of treating or preventing malaria comprising administering to an animal an effective amount of a compound of formula I:

description='In-line Formulae' end='lead'Q-Y—R1—R2  (I),description='In-line Formulae' end='tail'

wherein Q, Y, R1, and R2 are as described herein. Methods of inhibiting a plasmodial surface anion channel of a parasite in an animal are also provided. The invention also provides pharmaceutical compositions comprising a compound represented by formula I in combination with any one or more compounds represented by formulas II, V, and VI. Use of the pharmaceutical compositions for treating or preventing malaria or for inhibiting a plasmodial surface anion channel in animals including humans are also provided. Also provided by the invention are clag3 amino acid sequences and related nucleic acids, vectors, host cells, populations of cells, antibodies, and pharmaceutical compositions.

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Patent Owner(s)

Patent OwnerAddress
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICESMARYLAND 20892-7788

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Desai, Sanjay A Potomac, US 12 15

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