Collagen IV binding assay for the detection of collagen VII
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United States of America Patent
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Feb 16, 2021
Grant Date -
Jan 11, 2018
app pub date -
Jul 11, 2017
filing date -
Nov 7, 2012
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Abstract
The present disclosure features a method of detecting and/or quantifying collagen VII or a fragment thereof in a sample, the method including contacting the sample with collagen IV or a fragment thereof which binds to collagen VII; and contacting the sample with an anti-collagen VII antibody, wherein the anti-collagen VII antibody binds to the NC2 domain of collagen VII; detecting binding of the anti-collagen VII antibody to thereby detect and/or quantify an amount of collagen VII or the fragment thereof in the sample. A method of evaluating or processing a collagen VII preparation is also provided.
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