Methods for analyzing genomic variation within cells
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United States of America Patent
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Sep 1, 2020
Grant Date -
Jan 11, 2018
app pub date -
Feb 4, 2016
filing date -
Feb 4, 2015
priority date (Note) -
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Abstract
Methods, devices and systems for analyzing precious samples of cells, including single cells are provided. The methods, devices, and systems in various embodiments of the invention are used to assess genomic heterogeneity, which has been recognized as a central feature of many cancers and plays a critical role in disease initiation, progression, and response to treatment. The methods devices and systems are also used to analyze embryonic biopsies for preimplantation genetic diagnosis (PGD). In one embodiment, the devices, systems and methods provided herein allow for the construction of genomic and RNA-seq libraries without a pre-amplification step.
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