Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences

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United States of America Patent

PATENT NO 10829801
APP PUB NO 20180010172A1
SERIAL NO

15708039

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Abstract

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The present invention provides compositions, kits and methods for the selective hybridization and capture of a specific target nucleic acid. The specific target nucleic acid may be present in a heterogeneous mixture of nucleic acids. Selective hybridization and capture provides a target nucleic acid that is substantially free of non-target and/or contaminating nucleic acids. Target nucleic acids that have been selectively hybridized and captured using the current invention are then used in subsequent analysis, wherein the presence of non-target and/or contaminating nucleic acids that interfere with said subsequent analysis have been substantially reduced or eliminated, thereby providing improved analysis results. The invention offers the further advantage of requiring less stringent purification and/or sterility efforts than conventionally needed in order to ensure that enzymes and other reagents used in subsequent analysis, or present in the environment in which an assay is performed, are free of bacterial or other contaminating nucleic acids.

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Patent Owner(s)

Patent OwnerAddress
GEN-PROBE INCORPORATED10210 GENETIC CENTER DRIVE SAN DIEGO CA 92121 UNITED STATES OF AMERICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Becker, Michael M San Diego, US 73 1662
Lam, Wai-Chung Bonsall, US 16 309
Livezey, Kristin W Encinitas, US 27 493

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