Genetically modified microorganisms having improved tolerance towards L-serine
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United States of America Patent
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Oct 6, 2020
Grant Date -
Jan 11, 2018
app pub date -
Jan 27, 2016
filing date -
Jan 27, 2015
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Abstract
The present invention generally relates to the microbiological industry, and specifically to the production of L-serine or L-serine derivatives using genetically modified bacteria. The present invention provides genetically modified microorganisms, such as bacteria, wherein the expression of genes encoding for enzymes involved in the degradation of L-serine is attenuated, such as by inactivation, which makes them particularly suitable for the production of L-serine at higher yield. The present invention also provides means by which the microorganism, and more particularly a bacterium, can be made tolerant towards higher concentrations of serine. The present invention also provides methods for the production of L-serine or L-serine derivative using such genetically modified microorganisms.
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