Substituted imidazo[1,5-a]pyrazines as Btk inhibitors
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United States of America Patent
Stats
-
Aug 7, 2018
Grant Date -
Jan 11, 2018
app pub date -
Dec 17, 2015
filing date -
Dec 31, 2014
priority date (Note) -
In Force
status (Latency Note)
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Abstract
The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, Formula (I) or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.
First Claim
all claims..Other Claims data not available
Family
Country | kind | publication No. | Filing Date | Type | Sub-Type |
---|---|---|---|---|---|
WO | A1 | WO2016106626 | Dec 31, 2014 | Patent | Application |
Type : Patent Sub-Type : Application | |||||
INTERNATIONAL APPLICATION PUBLISHED WITH INTERNATIONAL SEARCH REPORT | IMIDAZOPYRAZINE ANALOGS WITH 3-TERTIARY CARBON SUBSTITUTIONS AS BTK INHIBITORS | Jul 07, 2016 | |||
WO | A1 | WO2016109220 | Dec 17, 2015 | Patent | Application |
Type : Patent Sub-Type : Application | |||||
INTERNATIONAL APPLICATION PUBLISHED WITH INTERNATIONAL SEARCH REPORT | IMIDAZOPYRAZINE ANALOGS WITH 3-TERTIARY CARBON SUBSTITUTIONS AS BTK INHIBITORS | Jul 07, 2016 | |||
EP | B1 | EP3240536 | Dec 17, 2015 | Patent | Grant |
Type : Patent Sub-Type : Grant | |||||
Patent | IMIDAZOPYRAZINE ANALOGS WITH 3-TERTIARY CARBON SUBSTITUTIONS AS BTK INHIBITORS | Apr 20, 2022 |
- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
MERCK SHARP & DOHME LLC | 126 EAST LINCOLN AVENUE RAHWAY NJ 07065 |
International Classification(s)

- 2015 Application Filing Year
- A61K Class
- 16157 Applications Filed
- 11882 Patents Issued To-Date
- 73.55 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Gao, Xiaolei | Bridgewater, US | 26 | 134 |
# of filed Patents : 26 Total Citations : 134 | |||
Guiadeen, Deodial Guy | Chesterfield, US | 16 | 16 |
# of filed Patents : 16 Total Citations : 16 | |||
Kozlowski, Joseph A | Princeton, US | 108 | 1669 |
# of filed Patents : 108 Total Citations : 1669 | |||
Liu, Jian | Edison, US | 667 | 5710 |
# of filed Patents : 667 Total Citations : 5710 | |||
Liu, Shilan | Shanghai, CN | 22 | 110 |
# of filed Patents : 22 Total Citations : 110 | |||
Wang, Dahai | Shanghai, CN | 22 | 32 |
# of filed Patents : 22 Total Citations : 32 |
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Patent Citation Ranking
- 0 Citation Count
- A61K Class
- 0 % this patent is cited more than
- 7 Age
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Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
---|---|---|---|---|
7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Feb 7, 2026 |
11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Feb 7, 2030 |
Fee | Large entity fee | small entity fee | micro entity fee |
---|---|---|---|
Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
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