RECOMBINANT METAPNEUMOVIRUS F PROTEINS AND THEIR USE

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United States of America Patent

SERIAL NO

15539640

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Abstract

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Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.

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Patent Owner(s)

Patent OwnerAddress
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICESOFFICE OF TECHNOLOGY TRANSFER NATIONAL INSTITUTES OF HEALTH 6701 ROCKLEDGE DRIVE SUITE 700 MSC 7788 BETHESDA MD 20892-7788

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Buchholz, Ursula Bethesda, US 20 74
Collins, Peter Kensington, US 37 416
Corti, Davide Bellinzona, CH 75 103
Joyce, Michael Gordon Washington, US 33 195
Kwong, Peter Washington, US 55 200
Lanzavecchia, Antonio Bellinzona, CH 80 1100
Stewart-Jones, Guillaume Bethesda, US 36 160
Yang, Yongping Potomac, US 33 106
Zhang, Baoshan Bethesda, US 35 163

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