METHOD AND COMPOSITIONS FOR ENHANCING IMMUNOTHERAPEUTIC TREATMENT OF A CANCER
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United States of America Patent
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Jan 11, 2018
app pub date -
Jul 5, 2017
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Jul 6, 2016
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Abstract
Provided are methods and compositions for enhancing treatment of a cancer by administering a therapeutic agent for the treatment of a cancer together with a second agent that elevates the level of protein p53. The second agent generates in the tumor a population of dendritic cells expressing at least one of Batf3, IRF5, CD103, and XCR1. The second therapeutic agent can also suppress an autoimmune response to non-cancerous tissue in the patient if generated by an immunotherapeutic agent. The method can further comprise administering a PTEN phosphatase inhibitor.
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