Methods for enhancing efficacy of therapeutic immune cells

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United States of America Patent

PATENT NO 10765699
APP PUB NO 20180008638A1
SERIAL NO

15548577

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to a method of using a receptor (e.g., chimeric antigen receptor—CAR) that activates an immune response upon binding a cancer cell ligand in conjunction with a target-binding molecule that targets a protein or molecule CI for removal or neutralization to generate enhanced anti-cancer immune cells. The present invention also relates to engineered immune cells having enhanced therapeutic efficacy and uses thereof.

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Patent Owner(s)

  • NATIONAL UNIVERSITY OF SINGAPORE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Campana, Dario Singapore, SG 51 1202
Kamiya, Takahiro Singapore, SG 24 145

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