Selective high-affinity polydentate ligands and methods of making such
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United States of America Patent
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May 12, 2020
Grant Date -
Jan 11, 2018
app pub date -
Sep 13, 2017
filing date -
Apr 21, 2008
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Abstract
This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.
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