Pteridine dione monocarboxylate transporter inhibitors
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United States of America Patent
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Jun 25, 2019
Grant Date -
Jan 11, 2018
app pub date -
Jan 22, 2016
filing date -
Jan 22, 2015
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Abstract
The invention provides compounds effective as inhibitors of monocarboxylate transporters such as MCT1 and MCT4, which can be used for treatment of medical conditions wherein treatment of the condition with a compound having an inhibitor effect on MCT1, MCT4, or both is medically indicated. Compounds of the invention can have antitumor, antidiabetes, anti-inflammatory, or immunosuppressive pharmacological effects, and can be effective for treatment of cancer and of type II diabetes.
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