GENETIC MARKERS PREDICTIVE OF RESPONSE TO GLATIRAMER ACETATE

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United States of America Patent

SERIAL NO

15410091

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention provides a method for treating a human subject afflicted with multiple sclerosis or a single clinical attack consistent with multiple sclerosis with a pharmaceutical composition comprising glatiramer acetate and a pharmaceutically acceptable carrier, comprising the steps of:

    (i) determining a genotype of the subject at a location corresponding to the location of one or more single nucleotide polymorphisms (SNPs) selected from the group consisting of: Group 1,(ii) identifying the subject as a predicted responder to glatiramer acetate if the genotype of the subject contains one or more A alleles at the location of Group 2,one or more C alleles at the location of Group 3,one or more G alleles at the location of Group 4, orone or more T alleles at the location of kgp18432055, kgp279772, kgp3991733 or kgp7242489; and (iii) administering the pharmaceutical composition comprising glatiramer acetate and a pharmaceutically acceptable carrier to the subject only if the subject is identified as a predicted responder to glatiramer acetate.

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Patent Owner(s)

Patent OwnerAddress
TEVA PHARMACEUTICAL INDUSTRIES LTD49131 PETACH-TIKVA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
GROSSMAN, Iris Yakir, IL 13 69
HAYARDENY, Liat Tel Aviv, IL 21 195
HAYDEN, Michael Petach-Tikva, IL 76 372
LADKANI, David Jerusalem, IL 12 118
ROSS, Colin James Douglas Burnaby, CA 3 18
TCHELET, Amir Hod-Hasharon, IL 5 45

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