Ribosome-mediated incorporation of peptides and peptidomimetics

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United States of America Patent

PATENT NO 10745705
APP PUB NO 20180002709A1
SERIAL NO

15545275

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Abstract

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Modified ribosomes that were selected using a dipeptidyl-puromycin aminonucleoside are used to mediate site-specific incorporation of one or more peptides and peptidomimetics into protein in a cell free translation system. In addition, new fluorescent dipeptidomimetics have been synthesized and incorporated into proteins, as well as modified proteins containing one or more non-naturally occurring dipeptides.

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Patent Owner(s)

Patent OwnerAddress
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY1475 N SCOTTSDALE ROAD SKYSONG - SUITE 200 SCOTTSDALE AS 85257

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dedkova, Larisa (Liza) Scottsdale, US 3 5
Hecht, Sidney Phoenix, US 48 174
Maini, Rumit Tempe, US 4 14
Paul, Rakesh Baltimore, US 6 16
Roy, Chowdhury Sandipan Tempe, US 3 5

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