VARIANTS OF GROUP 5 ALLERGENS OF THE TRUE GRASSES HAVING REDUCED ALLERGENEITY DUE TO MUTAGENESIS OF PROLINE RESIDUES

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United States of America Patent

APP PUB NO 20180002387A1
SERIAL NO

15700430

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Abstract

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The present invention relates to the preparation and use of recombinant variants of group 5 allergens of the Poaceae (true grasses), which are characterised by reduced IgE reactivity compared with known wild-type allergens and at the same time substantially retained reactivity with T-lymphocytes.

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Patent Owner(s)

Patent OwnerAddress
MERCK PATENT GMBHFRANKFURTER STRASSE 250 DARMSTADT 64293

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
CROMWELL, Oliver Suesel-Fassenberg, DE 31 52
FIEBIG, Helmut Schwarzenbek, DE 30 50
KAHLERT, Helga Hamburg, DE 9 10
NANDY, Andreas Hamburg, DE 18 27
REESE, Gerald Langen, DE 5 11
WALD, Martin Hamburg, DE 8 4
WEBER, Bernhard Hamburg, DE 23 44

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