Complexes of celecoxib and its salts and derivatives, process for the preparation thereof and pharmaceutical compositions containing them
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United States of America Patent
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Jun 4, 2019
Grant Date -
Jan 4, 2018
app pub date -
Dec 15, 2016
filing date -
Dec 16, 2015
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Abstract
Disclosed herein are stable complexes with controlled particle size, increased apparent solubility and increased dissolution rate comprising as active compound Celecoxib, its salts, or derivatives thereof, which is useful in the treatment of osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis, acute pain especially in cancer related acute pain, primary dysmenorrhea. More specifically, the complexes possess instantaneous redispersibility, increased apparent solubility and permeability that provide faster onset of action for acute pain relief and lower GI related side effects. Further disclosed are methods of formulating and manufacturing the complexes described herein, pharmaceutical compositions, and uses and methods of treatment.
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