INTESTINAL FXR AGONISM ENHANCES GLP-1 SIGNALING TO RESTORE PANCREATIC BETA CELL FUNCTIONS

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United States of America Patent

SERIAL NO

15697271

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Abstract

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Disclosed are embodiments of a method of treating or preventing latent autoimmune diabetes of adults (LADA) in a subject. Such embodiments include administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or farnesoid X receptor (FXR) agonist compounds, thereby activating FXR receptors in the intestines, and treating or preventing latent autoimmune diabetes of adults (LADA) in the subject.

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Patent Owner(s)

Patent OwnerAddress
SALK INSTITUTE FOR BIOLOGICAL STUDIES10010 N TORREY PINES ROAD LA JOLLA CA 92037-1002

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Atkins, Annette San Diego, US 29 172
Downes, Michael San Diego, US 82 715
Evans, Ronald M La Jolla, US 177 3476
Fang, Sungsoon La Jolla, US 7 43
Yoshihara, Eiji San Diego, US 8 42
Yu, Ruth T La Jolla, US 39 218

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