COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISORDERS
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United States of America Patent
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Dec 21, 2017
app pub date -
Dec 3, 2015
filing date -
Dec 3, 2014
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Abstract
Methods and compositions for drug discovery, analysis and treatment of a proliferative disorder characterized by abnormal cells in a mammalian subject are provided according to aspects of the present invention which include administering a pharmaceutically effective amount of a combination of: a cytotoxic agent, a SET agonist and a SET ribosome antagonist. Methods and compositions according aspect of the present invention incorporate agents effective to regulate and/or affect selective translation in a cell characterized by abnormal proliferation, such as a cancer cell, thereby promoting death of the cell.
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