Methods for production of functional beta cells
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United States of America Patent
Stats
-
Apr 28, 2020
Grant Date -
Dec 21, 2017
app pub date -
Jun 14, 2017
filing date -
Jun 21, 2016
priority date (Note) -
In Force
status (Latency Note)
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Abstract
The invention provides for methods of differentiating pancreatic endocrine cells into pancreatic beta cells expressing PDX1, NKX6.1, MAFA, UCN3 and SLC2A. These pancreatic beta cells may be obtained by step-wise differentiation of pluripotent stem cells. The pancreatic beta cells exhibit glucose-dependent mitochondrial respiration and glucose-stimulated insulin secretion similar to islet cells.
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International Classification(s)
- 2017 Application Filing Year
- A61K Class
- 21227 Applications Filed
- 12841 Patents Issued To-Date
- 60.50 % Issued To-Date
Cited Art Landscape
Patent Citation Ranking
- 0 Citation Count
- A61K Class
- 0 % this patent is cited more than
- 5 Age
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Oct 28, 2027 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Oct 28, 2031 |
