Antibodies reactive with B7-H3, immunologically active fragments thereof and uses thereof
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United States of America Patent
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Jun 16, 2020
Grant Date -
Dec 21, 2017
app pub date -
Jun 19, 2017
filing date -
Mar 4, 2010
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Abstract
The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies and their immunoreactive fragments that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.
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