Mu opioid receptor agonist analogs of the endomorphins

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United States of America Patent

PATENT NO 10919939
APP PUB NO 20170362276A1
SERIAL NO

15477907

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Abstract

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The invention relates to cyclic peptide agonists that bind to the mu (morphine) opioid receptor and their use in the treatment of acute and/or chronic pain. Embodiments of the invention are directed to cyclic analogs of endomorphin. These peptide analogs exhibit decreased tolerance relative to morphine, increased solubility compared to similar tetrapeptide analogs, while maintaining favorable or improved therapeutic ratios of analgesia to side effects.

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Patent Owner(s)

Patent OwnerAddress
THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND1430 TULANE AVE TB-32 NEW ORLEANS LA 70112-2632
DEPARTMENT OF VETERANS AFFAIRS (US)810 VERMONT AVENUE NW WASHINGTON DC 20420

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hackler, Laszlo Metairie, US 11 93
Zadina, James E Metairie, US 10 85

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