Formulations for targeted release of agents under low pH conditions and methods of use thereof
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United States of America Patent
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Jun 16, 2020
Grant Date -
Dec 21, 2017
app pub date -
Nov 18, 2015
filing date -
Nov 18, 2014
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Abstract
Poly(amine-co-ester-co-ortho ester) polymers, methods of forming active agent-load nanoparticles therefrom, and methods of using the nanoparticles for drug delivery are disclosed. The nanoparticles can be coated with an agent that reduces surface charge, an agent that increases cell-specific targeting, or a combination thereof. Typically, the loaded nanoparticles are less toxic, more efficient at drug delivery, or a combination thereof compared to a control or other transfection reagents.
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