Cysteine linked nanobody dimers

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United States of America Patent

PATENT NO 11426468
APP PUB NO 20170360955A1
SERIAL NO

15536751

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Abstract

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The present invention relates to dimers comprising a first polypeptide and a second polypeptide, wherein each of said first and second polypeptide comprises at least one immunoglobulin single variable domain (1ISVD) and a C-terminal extension comprising a cysteine moiety (preferably at the C-terminus), wherein said first polypeptide and said second polypeptide are covalently linked via a disulfide bond between the cysteine moiety of said first polypeptide and the cysteine moiety of said second polypeptide, in which the dimer outperformed the benchmark constructs, e.g. cognate multivalent and multispecific constructs, in various assays. The present invention provides methods for making the dimers of the invention.

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Patent Owner(s)

Patent OwnerAddress
ABLYNX N VTECHNOLOGIEPARK 21 ZWIJNAARDE 9052

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boutton, Carlo Wielsbeke, BE 56 373
Casteels, Peter Erpe-Mere, BE 13 77
Descamps, Francis Roeselare, BE 12 105
Janssen, Daniel Puurs, BE 6 26
Schotte, Peter De Pinte, BE 28 132

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