Modulation and detection of a neuronal alternative splicing regulatory network for treatment and diagnosis of neurological disorders
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United States of America Patent
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Sep 15, 2020
Grant Date -
Dec 21, 2017
app pub date -
Dec 15, 2015
filing date -
Dec 17, 2014
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Abstract
Methods for treatment and diagnosis of neurological disorders such as autism and autism spectrum disorder are disclosed. Also disclosed are modulators of alternative splicing regulators SRRM4 and/or SRRM3 for treating neurological disorders. Further disclosed are agents that modulate the expression of at least one splice variant for treating neurological disorders. Mouse models of neurological disorders having increased or decreased expression of SRRM4 and/or SRRM3 are also disclosed.
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