High specificity genome editing using chemically modified guide RNAs

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United States of America Patent

PATENT NO 10767175
APP PUB NO 20170355985A1
SERIAL NO

15493129

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Abstract

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The present invention relates to guide RNAs having chemical modifications and their use in CRISPR-Cas systems. The chemically modified guide RNAs have enhanced specificity for target polynucleotide sequences. The present invention also relates to methods of using chemically modified guide RNAs for cleaving or nicking polynucleotides, and for high specificity genome editing.

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AGILENT TECHNOLOGIES INC5301 STEVENS CREEK BOULEVARD SANTA CLARA CA 95051

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dellinger, Douglas J Boulder, US 83 3523
Roy, Subhadeep Lafayette, US 9 101
Ryan, Daniel E San Francisco, US 17 245
Sampson, Jeffrey R San Jose, US 41 2017

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