MORTALIN PEPTIDES AND ANTIBODIES AND USES THEREOF FOR INHIBITING MORTALIN ACTIVITY AND TREATING A DISEASE ASSOCIATED WITH A PATHOLOGICAL CELL
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Nov 19, 2015
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Nov 20, 2014
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Isolated mortalin peptides and antibodies are provided. Accordingly there is provided an isolated peptide comprising no more than 30 amino acids having a mortalin amino acid sequence and being capable of killing cancer cells and/or enhancing complement activity; also provided is an antibody comprising an antigen recognition domain having an amino acid sequence which binds mortalin and enhances complement-dependent cytotoxicity (CDC). Also provided are compositions and methods for inhibiting mortalin activity, killing a cell and treating a disease associated with a pathological cell population.
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