Fibronectin based scaffold domain proteins that bind to myostatin

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United States of America Patent

PATENT NO 10406212
APP PUB NO 20170354718A1
SERIAL NO

15491271

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Abstract

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The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.

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Patent Owner(s)

  • BRISTOL MYERS SQUIBB COMPANY

International Classification(s)

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  • 2017 Application Filing Year
  • A61K Class
  • 21227 Applications Filed
  • 12841 Patents Issued To-Date
  • 60.50 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2017201820192020202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cload, Sharon Cambridge, US 13 297
Corbett, Martin J Mount Holly, US 23 269
Engle, Linda Framingham, US 17 341
Kozhich, Alexander T Princeton, US 16 206
Lipovsek, Dasa Cambridge, US 81 1800
Madireddi, Malavi West Windsor, US 10 169
Rakestraw, Ginger Chao Somerville, US 14 276
Swain, Joanna Concord, US 12 169
Zhao, Wenjun Montgomery, US 32 230

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  • 1 Citation Count
  • A61K Class
  • 58.87 % this patent is cited more than
  • 6 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges11535744839711494311101 - 1011 - 2021 - 3031 - 4041 - 5051 - 6081 - 9091 - 1000500100015002000250030003500400045005000550060006500700075008000850090009500100001050011000115001200012500

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