METHOD FOR DETERMINING GENOTYPE OF PARTICULAR GENE LOCUS GROUP OR INDIVIDUAL GENE LOCUS, DETERMINATION COMPUTER SYSTEM AND DETERMINATION PROGRAM
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Dec 25, 2015
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Dec 26, 2014
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It is an invention aimed at providing methods for optimizing read information mapped to the particular gene loci such as MHC loci under a framework of probabilistic statistical processing. In the present invention, a step in which for all reads, calculation of the expected number of mappings to alleles of the particular gene loci is performed for read information in which mapping of reads to alleles of the particular gene loci is identified, a step in which the total number of expected mappings for each allele is calculated, and a step in which the fraction of reads allocated to each allele is calculated, are repeatedly executed, in which the optimization of read information is performed in a computer, and based on the optimized information, a method of easily and accurately estimating the genotypes of the particular gene loci, a computer system, and a computer program capable of easily and accurately estimating the genotype of the particular gene loci, are provided.
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