Genome editing with split Cas9 expressed from two vectors
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United States of America Patent
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Dec 8, 2020
Grant Date -
Dec 7, 2017
app pub date -
Nov 19, 2015
filing date -
Nov 19, 2014
priority date (Note) -
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status (Latency Note)
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Abstract
The present invention relates to a method for regulating gene expression, comprising introducing into a cell each of a recombinant vector which expresses a first domain comprising N-terminus of a Cas9 protein, and a recombinant vector which expresses a second domain comprising C-terminus of a Cas9 protein, a composition comprising the recombinant vectors, a kit for regulating gene expression, and a method for intracellular production of Cas9 protein. Moreover, the present invention relates to a transformed cell introduced with a viral vector which packages the first domain, and a viral vector which packages the second domain, and to a composition comprising a virus produced therefrom.
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