Functionalized particles having modified phases

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United States of America Patent

PATENT NO 10618920
APP PUB NO 20170349612A1
SERIAL NO

15173382

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Modified silica particles are provided. Aspects of the particles include an outer layer that is composed of organically-modified silica comprising a siloxane-linked hydrophilic group, such as a charged functional group or a polar neutral functional group. The modified silica particles can form the basis of a variety of chromatography support materials. Also provided are methods of preparing the subject particles. Aspects of the methods include contacting silica particles with water, an ionic fluoride and an organosilane reagent comprising a hydrophilic moiety to produce modified silica particles wherein the hydrophilic moiety of the organosilane reagent is incorporated into an outer layer of the silica particles. Chromatography supports and kits including the subject particles and methods of using the same are also provided.

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Patent Owner(s)

Patent OwnerAddress
AGILENT TECHNOLOGIES INC5301 STEVENS CREEK BLVD MS 1A-PB SANTA CLARA CA 95051-7201

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Wu Newark, US 99 645
Li, Yingyu Newark, US 1 3
Wang, Xiaoli West Chester, US 100 658
Wei, Ta-Chen Newark, US 17 132

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  • 2 Citation Count
  • C01B Class
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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges43138072101 - 1011 - 2021 - 3071 - 800255075100125150175200225250275300325350375400425450475

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