PHARMACEUTICAL FORMULATIONS AND METHODS OF USE THEREOF
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United States of America Patent
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Aug 16, 2017
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Nov 25, 2015
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Abstract
This disclosure is directed to antibody-drug conjugates. More specifically, this disclosure is directed to compositions comprising (i) antibody-drug conjugates comprising benzodiazepines, and (ii) a small hydrophobic molecule, methods of treatment using the compositions, and methods of formulating the compositions. Furthermore, this disclosure is directed to methods of reducing reversible self-association in antibodies and in antibody-drug conjugates.
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