Liquid pharmaceutical composition of etanercept with lysine and proline
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United States of America Patent
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Mar 30, 2021
Grant Date -
Dec 7, 2017
app pub date -
Dec 17, 2015
filing date -
Dec 22, 2014
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Abstract
The present invention relates to novel liquid protein formulations, particularly arginine-free liquid pharmaceutical compositions of etanercept. The invention employs particular combinations and classes of buffer systems, tonicifiers, and sugar stabilisers, optionally alongside polar ionisable amino acids (e.g. aspartic acid, glutamic acid, histidine, and lysine), to afford a viable and storable drug product.
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