Sequence variants

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United States of America Patent

PATENT NO 10711276
APP PUB NO 20170342422A1
SERIAL NO

15537925

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Amino acid residue misincorporations are necessarily found in sequence variants at low concentrations in admixture with expressed polypeptides, resulting from one or more base mismatches within codons susceptible to amino acid residue misincorporation during transcription and/or translation. The invention provides a method of optimizing the coding sequences of a polynucleotide that encodes a polypeptide, wherein at least one codon is susceptible to amino acid residue misincorporation. The method of the invention can be used to reverse-engineer an unknown coding sequence, which encodes the same polypeptide, but differs in said at least one codon from the known coding sequence. The method can further be used to alter the immunogenic potential of an expressed polypeptide. Thus, the invention is useful in engineering optimized polynucleotides encoding polypeptides.

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Patent Owner(s)

Patent OwnerAddress
SANDOZ AGVIADUKTSTRASSE 3 BASEL 4051

International Classification(s)

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  • 2015 Application Filing Year
  • C12Q Class
  • 3483 Applications Filed
  • 2244 Patents Issued To-Date
  • 64.43 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances201520162017201820192020202120222023202420250255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Achmüller, Clemens Kundl, AT 7 6
Fuchs, Michael Kundl, AT 72 431
Holzmann, Johann Kundl, AT 4 5
Toll, Hansjörg Kundl, AT 1 1

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Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges334613906117511101 - 1011 - 2021 - 3031 - 4041 - 5071 - 80100 +020040060080010001200140016001800200022002400260028003000320034003600

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