Sequence variants
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Jul 14, 2020
Grant Date -
Nov 30, 2017
app pub date -
Dec 18, 2015
filing date -
Dec 22, 2014
priority date (Note) -
In Force
status (Latency Note)
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Importance

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Abstract
Amino acid residue misincorporations are necessarily found in sequence variants at low concentrations in admixture with expressed polypeptides, resulting from one or more base mismatches within codons susceptible to amino acid residue misincorporation during transcription and/or translation. The invention provides a method of optimizing the coding sequences of a polynucleotide that encodes a polypeptide, wherein at least one codon is susceptible to amino acid residue misincorporation. The method of the invention can be used to reverse-engineer an unknown coding sequence, which encodes the same polypeptide, but differs in said at least one codon from the known coding sequence. The method can further be used to alter the immunogenic potential of an expressed polypeptide. Thus, the invention is useful in engineering optimized polynucleotides encoding polypeptides.
First Claim
all claims..Other Claims data not available
Family

- 15 United States
- 10 France
- 8 Japan
- 7 China
- 5 Korea
- 2 Other
Patent Owner(s)
Patent Owner | Address | |
---|---|---|
SANDOZ AG | VIADUKTSTRASSE 3 BASEL 4051 |
International Classification(s)

- 2015 Application Filing Year
- C12Q Class
- 3483 Applications Filed
- 2244 Patents Issued To-Date
- 64.43 % Issued To-Date
Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Achmüller, Clemens | Kundl, AT | 7 | 6 |
# of filed Patents : 7 Total Citations : 6 | |||
Fuchs, Michael | Kundl, AT | 72 | 431 |
# of filed Patents : 72 Total Citations : 431 | |||
Holzmann, Johann | Kundl, AT | 4 | 5 |
# of filed Patents : 4 Total Citations : 5 | |||
Toll, Hansjörg | Kundl, AT | 1 | 1 |
# of filed Patents : 1 Total Citations : 1 |
Cited Art Landscape
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Patent Citation Ranking
- 0 Citation Count
- C12Q Class
- 0 % this patent is cited more than
- 5 Age
Forward Cite Landscape
- No Forward Cites to Display

Maintenance Fees
Fee | Large entity fee | small entity fee | micro entity fee | due date |
---|---|---|---|---|
7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Jan 14, 2028 |
11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Jan 14, 2032 |
Fee | Large entity fee | small entity fee | micro entity fee |
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Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |
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