Structurally designed shRNAs
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United States of America Patent
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Jun 25, 2019
Grant Date -
Nov 30, 2017
app pub date -
Mar 6, 2017
filing date -
Apr 23, 2010
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Abstract
Provided is an improved design of shRNA based on structural mimics of miR-451 precursors. These miR-451 shRNA mimics are channeled through a novel small RNA biogenesis pathway, require AGO2 catalysis and are processed by Drosha but are independent of DICER processing. This miRNA pathway feeds active elements only into Agog because of its unique catalytic activity. These data demonstrate that this newly identified small RNA biogenesis pathway can be exploited in vivo to produce active molecules.
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