Aryl-cyanoguanidine compounds

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 10023539
APP PUB NO 20170342034A1
SERIAL NO

15534404

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

The present invention relates to protein-lysine N-methyltransferase SMYD2 (SET and MYND domain-containing protein 2) inhibitors, in particular SMYD2-inhibitory substituted cyanoguanidine-pyrazolines of general formula (I) wherein R1, R2, R3, R4, R5, X and r have the meaning as described and defined herein, as well as to pharmaceutical compositions comprising compounds according to the invention and to their prophylactic and therapeutic use for hyper-proliferative disorders, in particular for cancer, respectively tumor disorders. The present invention furthermore relates to the use of SMYD2 inhibitors for benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, neurodegenerative disorders, inflammatory disorders, atherosclerotic disorders and the control of male fertility.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddress
BAYER PHARMA AKTIENGESELLSCHAFTGERMANY

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Badock, Volker Berlin, DE 5 5
Barak, Naomi Berlin, DE 12 2
Brumby, Thomas Berlin, DE 34 193
Christ, Clara Berlin, DE 22 61
Crampton, Rosemary Helen Bollington, GB 2 0
Hillig, Roman Berlin, DE 18 45
Köhr, Silke Teltow, DE 6 3
Mowat, Jeffrey Stuart Berlin, DE 5 0
Stöckigt, Detlef Potsdam, DE 32 26
Stefanuti, Ian High Peak, GB 3 0
Stellfeld, Timo Berlin, DE 28 34
Stresemann, Carlo Berlin, DE 4 0
Ter, Laak Antonius Berlin, DE 34 105
Weiske, Jörg Berlin, DE 4 0

Cited Art Landscape

Load Citation

Patent Citation Ranking

Forward Cite Landscape

Load Citation

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
7.5 Year Payment $3600.00 $1800.00 $900.00 Jan 17, 2026
11.5 Year Payment $7400.00 $3700.00 $1850.00 Jan 17, 2030
Fee Large entity fee small entity fee micro entity fee
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00