Tetrafunctional bacteriophage
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United States of America Patent
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Oct 13, 2020
Grant Date -
Nov 30, 2017
app pub date -
May 12, 2014
filing date -
May 15, 2013
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Abstract
The invention provides a recombinant targeted bacteriophage for expressing a transgene in a target cell transduced with the bacteriophage. The bacteriophage comprises a first nucleic acid sequence encoding a pill capsid minor coat protein that is configured to display a cell-targeting ligand for enabling delivery of the bacteriophage to a target cell, a second nucleic acid sequence encoding at least one pVIII capsid major coat protein that is configured to display a foreign peptide thereon, and a transgene which encodes a protein which exerts a biological effect on the target cell.
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