Nanoparticles and their use in cancer therapy
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United States of America Patent
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Jun 23, 2020
Grant Date -
Nov 30, 2017
app pub date -
Dec 22, 2015
filing date -
Dec 23, 2014
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Abstract
The present invention provides a nanoparticle comprising a core comprising a metal; and a corona comprising a plurality of ligands covalently linked to the core, the plurality of ligands including at least a first species of ligand comprising an ethylene glycol portion and an amine group and at least a second species of ligand comprising a carbohydrate group, for use in a method of treating a cancer, particularly skin cancer, in a mammalian subject. Also disclosed are methods of treatment by administering the nanoparticles alone or in combination with radiotherapy.
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