STABLE PHARMACEUTICAL COMPOSITION COMPRISING PEMETREXED OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
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United States of America Patent
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Issued Date -
Nov 30, 2017
app pub date -
Nov 6, 2015
filing date -
Nov 17, 2014
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Abstract
Provided is a composition of a ready-to-use injectable solution comprising pemetrexed or pharmaceutically acceptable salts thereof, containing pemetrexed; anhydrous sodium sulfite; and N-acetyl-L-cystein. With respect to use as an injectable preparation. The ready-to-use injectable solution composition is suitable for effective administration of pemetrexed since a melting process of main ingredients is not necessary before administration, and the composition can be used by being diluted immediately in a perfusate. In addition, the properties of the composition do not change even in long-term storage, and pharmaceutical stability is significantly improved by inhibiting related substances below a reference, whereby the composition can be stored in a liquid preparation state.
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