FUSION PROTEINS CONTAINING RECOMBINANT CYTOTOXIC RNASES
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United States of America Patent
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Nov 23, 2017
app pub date -
Aug 2, 2017
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Feb 13, 2004
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Recombinant immunotoxins containing a cytotoxic RNAse fused to an antibody or antibody fragment may be produced in mammalian cell culture. Surprisingly, immunotoxins containing a cytotoxic RNAse fused to the N-terminus of one antibody variable domain can be prepared and retain the ability to specifically bind antigen. The immunotoxins may lie used in a variety of therapeutic methods for treating diseases or syndromes associated with unwanted or inappropriate cell proliferation or activation.
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