N-substituted beta-carbolinium compounds as potent P-glycoprotein inducers
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United States of America Patent
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Sep 11, 2018
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Nov 23, 2017
app pub date -
Oct 21, 2015
filing date -
Oct 21, 2014
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Abstract
The present invention relates to the N-substituted beta-carbolinium compounds of general formula A and formulae I and II wherein, R1 and R2 groups are selected from halogens or trifluoromethyl; R3 group is selected from hydrogen or methyl; Ar is selected from aryl and heteroaryl, X is selected from halogens; and R1 and R2 groups may be attached to any position on ring E. The present invention particularly relates to synthesis and p-glycoprotein induction activity of the N-substituted beta-carbolinium compounds. In addition, the invention relates to methods of using compounds for treating or preventing Alzheimer's disease.
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